Adenosine-substituted derivatives are promising inhibitors against the sleeping sickness,49 and as antitumor agents,50 while building block connection at 5′ position via an amide or sulfonamide functionality led to potent inhibitors of salicyl-AMP ligase (MbtA),51 anthranilyl-CoA synthetase PqsA52 as well as catechol-O-methyltransferase (COMT),53 and most recently of the SARS-CoV-2 nsp14 guanine-N7 MTase, among others.54–57. This evidence concerns the gene COMT and human African trypanosomiasis.