LPL and metabolic syndrome: This variant was also reported as the most common LPL-FCS-causing variant in a cohort from the Spanish dyslipidemia registry7 and second most common in a cohort of FCS from Canada, where the most common LPL variant was the c.701C>T p.(Pro234Leu) missense variant5 that was only observed in 2 MCS individuals in heterozygous state in our cohort.