Thus, this study aimed to investigate the antihypertensive effects (such as inhibition of ACE, decreasing SBP, decreasing DBP, as well as increasing urine volume and increase in nitric oxide and nitrate oxide levels) ofP. americana leaf extracts and nanoparticlesin vivo involving male Wistar rats to develop potential natural materials ofP. americana leaves in an attempt to control the prevalence of hypertension, especially in Sarolangun Regency, Jambi. This evidence concerns the gene ACE and hypertensive disorder.