NLRP3 and nervous system disorder: The NLRP3-mediated inflammatory responses are significant for neurological diseases [22–25]: elevating the level of NLRP3 can trigger the maturation and subsequent release of such inflammatory cytokines as IL-1β, promoting inflammatory responses [26], while restraining NLRP3 or components of the inflammasome helps to ease neuroinflammation and neurodegenerative changes, thereby greatly improving the cognitive functions [27–29].