PTRH1 and bacterial infectious disease: Under conditions of translational stress caused by stalled protein synthesis, misfolded protein accumulation, or nutrient deprivation, Pth1 maintains cellular homeostasis through its dual function of catalyzing peptidyl moiety release from stalled peptidyl-tRNA complexes and preserving the free tRNA pool, making it not only essential for cell survival but also a promising therapeutic target for combating bacterial infections (Mundra and Kabra, 2024).