Snai2 is enriched in basal prostate stem cell (mPSC) populations, and the increased organoid formation capacity of mPSC Snai2+ populations mediates TMPRSS4-induced increases in SOX2 and ALDH activity and the acquisition of CSC-like signatures in prostate cancer (9, 10). The gene discussed is SNAI2; the disease is Familial prostate cancer.