SNAI2 and leukemia: Snai2 negatively regulates the self-renewal of normal hematopoietic stem cells, but the expression of Snai2 in acute myeloid leukemia (AML) promotes the development of leukemia, and the loss of Snai2 expression impairs the self-renewal of leukemia stem cells (LSCs) through the Slc13a3/ROS pathway and significantly prolongs the survival of individuals (8).