As hepatic echinococcosis progresses, the lesion may compress or infiltrate the liver parenchyma, thereby leading to impaired liver synthetic function, as indicated by decreased levels of coagulation factors II, V, VII, and X, prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT), and consequently elevated risk of intraoperative bleeding. This evidence concerns the gene F2 and echinococcosis.