RUNX1 and chronic myelomonocytic leukemia: WES of Case 1 (familial CMML) revealed three somatic mutations: RUNX1 c.928del [p.Met310Ter; variant allele frequency (VAF), 42.3%], SRSF2 c.284C>A (p.Pro95His; VAF, 45%), and multi-hit TET2 mutations [TET2 c.3803 + 1G>A, a splice site mutation (VAF, 46.6%) and c.3965T>C (p.Leu1322Pro), a missense mutation (VAF, 44.9%)].