CTSB and memory impairment: The miR‐96‐5p agomirs also significantly suppressed astrocyte reactivity in 3×Tg mice (Figure 6L,M).To confirm the important role of CTSB in the astrocyte reactivity and memory impairments, CA‐074, a Cathepsin B inhibitor [26], was intraperitoneally injected into 3×Tg mice at a dosage of 10 mg/kg for 15 days to inhibit CTSB expression (Figure 7A).