Notably, this regulatory mechanism persists in gastric cancer peritoneal metastases, with proteomic studies confirming that HIF‐1α establishes an SLC7A11‐mediated antioxidant defense system by inducing peritoneal metastasis‐associated protein (PMAN) expression, thereby maintaining lipid metabolic homeostasis in metastatic niches [494, 495]. Here, SLC7A11 is linked to gastric cancer.