Notably, the neuroprotective agent dimethyl fumarate demonstrates potent antiferroptotic effects in rat models of chronic cerebral ischemia by activating the NRF2 signaling axis to upregulate IκBα expression, concurrently suppressing NF‐κB activation and promoting antioxidant protein expression including heme oxygenase‐1 (HMOX1), NAD(P)H quinone dehydrogenase 1 (NQO1), and GPX4 [194]. This evidence concerns the gene NQO1 and brain ischemia.