Notably, 8‐OHG released under GPX4 deficiency activates the STING (stimulator of IFN genes) pathway, driving aberrant expression of inflammatory mediators such as IL‐6 and NOS2 (nitric oxide synthase 2), providing new insights into pancreatic cancer inflammatory microenvironment formation [578]. The gene discussed is NOS2; the disease is familial pancreatic carcinoma.