In tumor immune regulation, CD8+ T cell‐derived IFN‐γ exerts multidimensional control: it disrupts the oxidative defense barrier of tumor cells by suppressing the SLC7A11‐mediated cystine transport system, while simultaneously activating ACSL4 to catalyze biosynthesis of PUFA phospholipids such as AA. This evidence concerns the gene ACSL4 and neoplasm.