Notably, M1 macrophages demonstrate superior IFN‐γ production capacity [627], and dual PD‐1/TGF‐β blockade not only strengthens M1 polarization but also induces tumor‐specific ferroptosis through Fenton reactions between elevated H2O2 levels in macrophages and metal ions released from nanoparticles [628]. This evidence concerns the gene IFNG and neoplasm.