This assembly will induce the formation of activate caspase‐1, which cleaves gasdermin D to initiate pyroptosis and facilitates the maturation of IL‐1β and IL‐18, contributing to the development of inflammatory diseases including colitis [3], cryopyrin‐associated periodic syndrome [4], type 2 diabetes (T2D) [5], gout [6], atherosclerosis [7], and peritonitis [8]. Here, IL18 is linked to colitis.