According to the molecular mechanism, HOTAIRM1 may improve PTBP1 and IGF2BP2's association, entice them to bind to SHMT2 mRNA, and then boost the quantity of SHMT2 protein by improving the stability of its mRNA, resulting in mitochondrial activity and the malignant growth of glioma [141]. Here, IGF2BP2 is linked to central nervous system cancer.