Within the HS group, left hippocampal minimum perfusion levels showed positive correlations with the CAPE total (r65 = 0.25, pdiff = .018) and depression (r65 = 0.39, pdiff = .016) scores, the DASS total (r66 = 0.29, pdiff = .002) and depression (r66 = 0.33, pdiff = .003) scores, and the SPQ disorganized (r65 = 0.25, pdiff = .006) and excessive social anxiety (r65 = 0.30, pdiff = .002) subscales. Here, SMC2 is linked to major depressive disorder.