LGI1 and encephalitis: Neuroimaging techniques have revealed significant functional and structural abnormalities in brain regions that are implicated in emotions, memory, and seizures in patients with anti-LGI1 encephalitis, including the medial temporal lobe, amygdala, hippocampus, cingulate cortex, and insula (Finke et al., 2017; Hang et al., 2020).