Routine laboratory investigations revealed: (1) marked hypercalcemia: 121 mg/L (reference range: 85-105 mg/L); significantly elevated parathyroid hormone (PTH): 385 pg/mL (reference range: 15-65 pg/mL), representing nearly six times the upper normal limit; and elevated alkaline phosphatase: 1,230 IU/L (reference range: 45-129 IU/L). The gene discussed is PTH; the disease is hypercalcemia disease.