Similar trends have been reported in patients with acute myocardial infarction, where a U-shaped relationship between LDL and mortality was observed only among those with high CRP, suggesting that inflammation modifies the lipid-CVD risk relationship [22]. Taken together, these findings reinforce the clinical relevance of our results, suggesting that inflammation-driven lipid suppression may not only obscure CV risk but also contribute independently to adverse outcomes, highlighting the need for inflammation-adjusted risk stratification in both acute and chronic care settings. Here, CRP is linked to myocardial infarction.