Histologically, it demonstrates superficial and deep dermal involvement by monotonous, intermediate- to large-sized diffuse sheets of centroblasts and immunoblasts, large neoplastic cells with round oval nuclei, vesicular chromatin and prominent nucleoli, tumor necrosis may be observed, high mitotic activity with Ki-67 proliferation index exceeding 70% in most cases [9]. The gene discussed is MKI67; the disease is neoplasm.