Glandular fibrosis is an irreversible morphological change in the advanced stage of the disease, directly resulting in glandular atrophy and loss of function [84,85]. Studies have confirmed that the pro-fibrotic effect of TGF-β1 is related to its regulation of the SMAD/Snail signaling pathway, while inhibition of the TGF-β1 signal can effectively reduce the fibrosis of EGs in SS patients [86,87]. This evidence concerns the gene TGFB1 and synovial sarcoma.