More importantly, calprotectin has been shown to strongly induce immune cells to express IL-1β, IL-6, TNF-α, and IFN-γ, thereby participating in the inflammatory response of SGs in SS patients [57]. Therefore, some studies suggest that calprotectin has the potential to be a biological marker for SS [58]. However, regrettably, there are currently few studies on the relationship between calprotectin and the pathogenesis of SS, and more potential mechanisms need to be further explored in the future. The gene discussed is TNF; the disease is synovial sarcoma.