IL1B and synovial sarcoma: More importantly, calprotectin has been shown to strongly induce immune cells to express IL-1β, IL-6, TNF-α, and IFN-γ, thereby participating in the inflammatory response of SGs in SS patients [57]. Therefore, some studies suggest that calprotectin has the potential to be a biological marker for SS [58]. However, regrettably, there are currently few studies on the relationship between calprotectin and the pathogenesis of SS, and more potential mechanisms need to be further explored in the future.