CASP1 and synovial sarcoma: NOD-like receptor pyrin domain-containing 3 (NLRP3) is the primary inflammasome that undergoes hyperactivation by undegraded dsDNA in SS-associated macrophages [68]. NLRP3 and its related inflammatory factors, including caspase-1, IL-1β, and IL-18, have also been shown to be significantly upregulated in the EGs of SS patients [69]. Absent in melanoma 2 (AIM2), an IFN-γ-induced protein, is thought to play a key role in the inflammasome formation of macrophages induced by dsDNA.