The polarization of M2 macrophages is driven by IL-4 and IL-13, and is characterized by the marked expression of TGF-β and IL-10 [46]. The SGs of SS patients exhibit high expression of chemokines including CXCL9, CXCL10, and CXCL11 [47]. These elevated chemokines primarily mediate the migration of CXCR3+ T lymphocytes into the SGs [48]. Therefore, in some studies, treatment with anti-CXCR3 antibody has been shown to significantly reduce the infiltration of T lymphocytes in the SGs [49]. The gene discussed is TGFB1; the disease is synovial sarcoma.