dsDNA: Anti-double stranded DNA; SS-A: Anti-Sjögren's syndrome-related antigen A antibody; Ro-52: anti-TRIM21 antibody; SS-B: anti-Sjögren's syndrome type B antibody; RNP/sm: anti-Smith/ribonucleoprotein antibodies; sm: anti-Smith antibodies; SCL-70: anti-topoisomerase I antibody; PML-SCL: polymyositis-scleroderma 100 antibody; Jo-1: anti-histidyl tRNA synthetase antibody; PCNA: anti-proliferating cell nuclear antigen antibody; AMA-M2: anti-mitochondrial M2 antibody. The gene discussed is TRIM21; the disease is scleroderma.