NRAS is only rarely mutated in uveal melanoma, so an NRAS-positive/BRAF-wild-type genotype points to a cutaneous origin [11]. In cutaneous melanoma, >80% of NRAS mutations occur at Q61 (exon 2) or, less often, at codon 12 (exon 1) and co-exist with BRAF V600E in <1% of treatment-naïve tumors [11-14]. This evidence concerns the gene NRAS and uveal melanoma.