WFDC2 and cancer: CA 125, CA 19-9, and human epididymis secretory protein 4 (HE4) have all been evaluated, and the Risk of Ovarian Malignancy Algorithm (ROMA) algorithm (which combines CA 125, HE4, and menopausal status) has demonstrated superior accuracy in distinguishing borderline or malignant tumors from benign cysts [12].