Notably, the anti-proliferative effect of REDD2 was comparable to that of the expression of CDKN2A-p16 (Supplementary Fig. S5A and B); a well-established tumor suppressor, which blocks the cell cycle by inhibiting CDK4 and CDK6 and is frequently deleted or mutated in melanoma [38, 39]. This evidence concerns the gene CDK4 and neoplasm.