Comparison of the expression patterns of the m5C machinery across breast cancer subtypes revealed that the m5C methyltransferase NSUN5 and the readers ALYREF, YBX1, and YBX2 were overexpressed in the basal subtype relative to normal tissue (Fig. 2A and Supplementary Fig. S4A–M). The gene discussed is YBX2; the disease is breast cancer.