LRRK1 is known to play a role in OC function; the disruption of which results in disease phenotypes in humans (osteopetrosis and osteosclerotic metaphyseal dysplasia)38 and mice lacking the gene show severe osteopetrosis, increased bone mineralization, and decreased bone resorption.39 This evidence concerns the gene LRRK1 and osteosclerotic metaphyseal dysplasia.