IGHE and Alzheimer disease: Likewise, in AD mouse model, scutellarein was reported to inhibit TRPV3 channel activity, accompanied by reduced, accompanied by reduced neural hyperexcitability, lower serum IgE levels, and decreased expression of proinflammatory cytokines including IL-1β, TNF-α, IL-4, IL-6, and CXCL15 (Wang Y. et al., 2022).