CXCL1 and Erythema: Among them, C-X-C motif chemokine ligand 1 and 2 (CXCL1 and CXCL2) are significantly upregulated in lesional skin and primarily mediate neutrophil recruitment through interaction with the CXCR2 receptor, thereby aggravating tissue damage and acute symptoms such as erythema and edema (Sakai et al., 2021).