In addition, in a Dermatophagoides farinae extract and DNCB-induced AD mouse model, rutin was reported to downregulate Th2-type cytokines including IL-31, IL-4, and IL-13, along with decreased serum histamine levels and suppressing mast cell infiltration in lesional skin (Choi and Kim, 2013). The gene discussed is IL4; the disease is Alzheimer disease.