FLG and Alzheimer disease: Myricetin has been reported to increase lamellar body secretion and support the structural integrity of the epidermal lipid matrix in AD mouse model (Gao et al., 2023), while apigenin has been reported to increase the expression of AQP3, HAS, and filaggrin, upregulates skin hydration and lipid synthesis, increase lamellar body density, and increase the expression of lipid-synthesizing enzymes, indicating potential roles in epidermal hydration and barrier maintenance in cell models (Hou et al., 2013; Park C.-H.