IL4 and Alzheimer disease: For instance, Daphnopsis costaricensis Barringer and Grayum extract identified with 11 flavonoid metabolites and stechamone were observed to suppresse β-hexosaminidase release, reduce mast cell degranulation and IL-4 production, and were associated with attenuated scratching behavior in mouse AD models (Jo et al., 2018; Bae et al., 2022).