Similarly, quercetin and its derivatives have been shown to downregulate the expression of iNOS, COX-2, and Th2-associated cytokines (IL-4, IL-5, and TSLP), while reducing serum IgE levels and eosinophil counts in AD mouse model, suggesting that they may concurrently mitigate oxidative stress and modulate immune responses (Jafarinia et al., 2020). This evidence concerns the gene IGHE and Alzheimer disease.