Supporting this mechanism, Qiu et al. (2023) reported that curcumin significantly improved several Metabolic Syndrome-associated inflammatory markers, including tumor necrosis factor-α (TNF-α), CRP, and malondialdehyde (MDA), though interleukin-6 (IL-6) and high-sensitivity CRP (hsCRP) showed no significant changes. The gene discussed is IL6; the disease is metabolic syndrome.