By summarizing data from the animal literature, we conclude the mechanisms of curcumin for chronic diseases combined with anxiety/depressive are mainly focused on the following aspects: (1) Anti-inflammatory and antioxidant effects: for diabetes, obesity or pain, curcumin can reduce pro-inflammatory cytokines (TNF-α, IL-6) and regulate pathways such as NF-κB. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.