For example, the histone methyltransferase gene KMT2D (also known as MLL2) and the histone demethylase gene KDM6A (UTX) are mutated in approximately 20%–30% of bladder cancers, as reported by The Cancer Genome Atlas (TCGA) analyses (Schulz et al., 2019). Here, KMT2D is linked to urinary bladder carcinoma.