Intriguingly, age-related changes in tissue often involve shifts in PRC2 activity–for instance, stem cells in older organisms exhibit altered PRC2 targets - which may help explain why EZH2 is frequently overexpressed in high-grade, muscle-invasive bladder tumors and is correlated with shorter time to recurrence (Piunti et al., 2022). Here, EZH2 is linked to urinary bladder neoplasm.