This epigenetic silencing of CDKN2A is especially noteworthy in the context of aging: while normal elderly cells rely on CDKN2A upregulation to enforce senescence, bladder tumor cells can epigenetically shut down CDKN2A expression, thus evading an age-imposed growth arrest (Safwan-Zaiter et al., 2022). Here, CDKN2A is linked to urinary bladder neoplasm.