KDM6A and breast cancer: KDM6A, an X-chromosome escapee histone-demethylase, is expressed from both alleles in females but from a single allele in males; functional loss abolishes the female survival advantage in murine urothelial carcinogenesis and correlates with reduced CD8+ infiltration in human BC(Kaneko and Xue, 2018; Chen et al., 2021a).