WNK2 and Cerebral ischemia: Some studies have also established a model of cerebral ischemia–reperfusion injury and found that HSYA inhibits the opening of the mitochondrial permeability transition pore and limits the output of mitochondrial cytochrome C (CytC) by regulating the mitogen-activated protein kinase (MAPK) signaling pathway, thus helping to improve cerebral ischemia–reperfusion injury (Huang et al., 2021).