Figure 10B depicts the chemical structure of TSA. The clustering result obtained from the L1000CDS2 analysis showed that for the uploaded COVID-19 gene signature, TSA may reverse the expression of serpin family H member 1 (SERPINH1), lysophosphatidic acid receptor 1 (LPAR1) and transcription elongation factor A2 (TCEA2). Furthermore, in the MDD gene signature, TSA may reverse the expression of nucleolar protein 3 (NOL3), LPAR1 and heat shock protein family A member 6 (HSPA6) (Figure 10C). Here, SERPINH1 is linked to COVID-19.