Abrogation of PD fluid-induced SGLT2 transcriptional upregulation by i.p. dapagliflozin, Reduced Peritoneal Fibrosis and Ultrafiltration Failure, Reduced Submesothelial Microvessel Density, Abrogates Proinflammatory Signaling. The gene discussed is SLC5A2; the disease is fibrosis.