In the context of Parkinson’s disease treatment, inhibiting USP30 increases translocase of outer mitochondrial membrane 20 (TOM20) ubiquitination and promotes mitophagy, offering a potential therapeutic strategy for Parkinson’s disease caused by PTEN-induced kinase 1 (PINK1) or Parkin mutations (Fang et al., 2023). The gene discussed is PINK1; the disease is Parkinson disease.