Studies have shown that USP30 promotes the proliferation of hepatocellular carcinoma cells by positively regulating dynamin-related protein 1 (DRP1)-related mitochondrial fission (Gu et al., 2018) and inhibits apoptosis in leukemia cells by suppressing Parkin-mediated mitophagy and enhancing protein kinase B/mechanistic target of rapamycin (AKT/mTOR) activity (Zhang R. et al., 2022). Here, AKT1 is linked to hepatocellular carcinoma.