Recently, DUB sub-families have gained research attention for their specific deubiquitination preferences and vital roles in biological processes, linking them to diseases like cancer, cardiovascular issues, inflammatory disorders, and neurodegenerative conditions (Popovic et al., 2014; Melo-Cardenas et al., 2016; Singhal et al., 2008; Reyes-Turcu et al., 2009; Huang et al., 2023; Liu et al., 2025; Chen S. et al., 2021). This evidence concerns the gene ZUP1 and cancer.