USP30 is highly expressed in diverse malignancies, such as hepatocellular carcinoma (HCC), breast cancer (BC), glioblastoma (GBM), colon cancer, acute myeloid leukemia (AML), cervical cancer (CC), oral squamous cell carcinoma (OSCC), bladder urothelial carcinoma (BLCA), ovarian carcinoma (OC), and melanomas. Here, USP30 is linked to hepatocellular carcinoma.