Other studies have recently shown that HSP60 (heat shock protein 60), a chaperone mainly localized in the mitochondrial matrix where it accounts for the transportation and refolding of proteins from the cytoplasm directly into the mitochondrial matrix, has been found to be commonly over-expressed in NSCLC and associated with poor prognosis [10,11]. This evidence concerns the gene HSPD1 and non-small cell lung carcinoma.