KRAS and cancer: MicroRNA let-7a, a post-transcriptional regulator of K-RAS involved in terminal differentiation and tumor suppression, is downregulated in cancers with poor prognosis, and studies show that combined treatment with sulforaphane, quercetin, and EGCG extract induces miR-let-7a expression and inhibits K-RAS in highly tumorigenic MIA-PaCa2 cell lines [121].