Pterostilbene also promoted chemosensitivity by inducing S-phase cell cycle arrest, apoptosis, and autophagic cell death and by inhibiting multidrug resistance protein 1 (MDR1) expression, downregulating receptor for advanced glycation end-products (RAGE)/PI3K/Akt signaling in gemcitabine-resistant PC cells [112]. The gene discussed is ABCB1; the disease is pachyonychia congenita.