FOXO3 and pancreatic neoplasm: Shankar et al. found that EGCG inhibits the growth of human pancreatic tumors implanted in mice by reducing the phosphorylation of ERK, PI3K, Akt, and forkhead transcription factor like 1/forkhead box O3a (FKHRL1/FOXO3a), and modulating FOXO target genes [122].