MAPK1 and pachyonychia congenita: Cao et al. found that resveratrol inhibits the hyperglycemia-induced activity of PC cells, including the production of ROS and H2O2, expression of urokinase-type plasminogen activator (uPA), E-cadherin, and glucose transporter 1 (Glut-1), and activation of ERK, p38 MAPK, and NF-κB signaling pathways, indicating mechanisms for the chemoprevention of PC [95].