Other in vitro assays using Panc-1 and BxPC-3 cell lines exposed to 50 μM and 100 μM of resveratrol for 24 h, in a subcutaneous xenograft model of PC treated with doses of 50 mg/kg of resveratrol, have shown a decrease in stem cell markers (sex determining region Y)-box 2 (SOX2), nanog homeobox (NANOG), organic cation/carnitine transporter 4 (OCT4), resulting in the reduction of expression of nutrient-deprivation autophagy factor 1 (NAF-1), a genetic locus expressed in PC tissue which correlates with progression [92]. Here, SOX2 is linked to pachyonychia congenita.