SORBS1 and familial pancreatic carcinoma: Given that PPH downregulated SORBS1 expression (Fig. 2B) and that SORBS1 knockdown promoted cell proliferation in pancreatic cancer (Fig. 4B), this study hypothesized that PPH-induced SORBS1 downregulation by PPH could attenuate the restraining influence of PPH on the expansion of pancreatic cancer cells.