Moreover, while tumor volumes were lower in both the PPH-treated SORBS1-blank and the SORBS1-knockdown groups compared with their respective controls, comparing the SORBS1-knockdown + PPH group with the SORBS1-blank group uncovered that SORBS1 knockdown attenuated the inhibitory effect of PPH on pancreatic cancer. The gene discussed is SORBS1; the disease is pancreatic neoplasm.