32 CCA patients (IHCC, EHCC, gallbladder, ampullary) with both HER2 positive (IHC3+ or IHC2+/ISH+) HER3-low (IHC2+/ISH-, IHC1+/ISH+, or IHC0/ISH+. This evidence concerns the gene ERBB2 and cholangiocarcinoma.