On the other hand, G-CSF shows beneficial effects in alleviating intestinal inflammation by enhancing tissue migration of neutrophils, improving immunodeficiency and protecting the intestinal barrier [7, 8, 21, 22]; for example,rhG-CSF has been shown to significantly reduce epithelial cell apoptosis and inflammatory responses in animal models [7], with clinical studies confirming its safety and therapeutic potential [8]. This evidence concerns the gene CSF3 and immunodeficiency disease.