CYP17A1 and pachyonychia congenita: To further refine our approach, we evaluated the inhibitorypotential of these compounds on the CYP17A1 enzyme, which is criticalfor androgen synthesis and is implicated in advanced stages of PC.This involved identifying substituents that would effectively interactwith the active site of CYP17A1, based on electronic properties thatstrengthen coordination between HEM iron and carbonyl oxygen.