SEC61A1 and cancer: Ipom-F is a highly potent cytotoxic natural product with IC50s of low nM for many cancer cell lines. Although the molecular target of Ipom-F, Sec61-α,is ubiquitously required for synthesizing membrane and secretory proteinsin most eukaryotic cells, our previous studies demonstrated that Ipom-Fdifferentially affected the viability of different cancer cells.