In patients with non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina (UA), myocardial ischemic injury leads to a decrease in Cx43 expression, lateral changes in distribution, and a significant increase in dephosphorylation, which is positively correlated with the severity of myocardial ischemia (46). Here, GJA1 is linked to myocardial ischemia.