In cultured murine melanoma B16F1 cells and THP‐1 cells, methanolic extracts of fenugreek seed inhibited the yield of phorbol‐12‐myristate‐13‐acetate‐induced inflammatory cytokines like tumor necrosis factor (TNF)‐a (Kawabata et al. 2011). This evidence concerns the gene TNF and melanoma.