Notably, JUNB’s overexpression correlates with autophagy inhibition, as evidenced in an osteoarthritis model, indicating a potential promotion of articular cartilage degradation by JUNB through autophagy suppression (83).Recent studies have indicated that upregulation of JUNB impairs hepatic lipid metabolism in mice, while inhibition of JUNB can alleviate lipid accumulation in the liver (84). This evidence concerns the gene JUNB and osteoarthritis.