Switching the SS#4IgG back to its initial developmental IgM state, which eliminates self-association, and reverting all the somatic mutations in the IGHV-D-J to their germline sequences leads to an IG that reacts significantly with apoptotic cells and ss- and ds-DNA; both typical for most CLL IGs. The gene discussed is CD40LG; the disease is B-cell chronic lymphocytic leukemia.