FHL1 and hemolytic-uremic syndrome: While desialylation of the plasma proteins transferrin and proteins in the FH family, including FH, Factor H-like 1 (FHL-1) and Factor H Related (FHR) 1-5, have been previously described in SP-HUS patients, further processing of N-glycans, including loss of galactose and GlcNAc as we have seen in our patients, has not been reported (16, 37).