To further elucidate the role and underlying mechanisms of Circ_0007552 in lung adenocarcinoma (LUAD) and bone metastasis (BM) in nude mice, H1299 and SPCA1 cells stably expressing sh-Circ_0007552 or sh-NC, as well as H838 and PC-9 cells stably transfected with Circ_0007552-overexpressing (OE-Circ_0007552) or negative control (OE-NC) vectors, were injected into the right axilla and bilateral tibiae of nude mice. Here, ATP2C1 is linked to lung adenocarcinoma.