JAK3 and synovial sarcoma: Considering the mutation frequencies obtained from the RNA-seq data for this group of genes, we also observed that JAK3, NCOR1, PDCD11, RHOA, TET2 and TP53, all strongly implicated in SS, had a higher mutation frequency (≥17% of the samples), a finding that reflects both the presence of their unfiltered germline variants and, more importantly, their effective transcription in SS cells.