We identified 11 prognostic URGs and DRGs, and there were 5 genes (CCNF, APP, NEURL3, CCNE1, AURKA) up-regulated, and 6 genes (FBXW5, TRIM13, NBR1, ANXA11, MAPK14, and CFTR) down-regulated in the ESCC group. The gene discussed is APP; the disease is esophageal squamous cell carcinoma.