Although it has been revealed that overexpression of NEURL3 suppressed NPC cell migration, invasion, and metastasis by promoting the degradation of Vimentin through increasing its K48-linked polyubiquitination (40), the biological function of NEURL3 in the tumorigenesis and progression, especially in ESCC, has not been thoroughly investigated. The gene discussed is NEURL3; the disease is esophageal squamous cell carcinoma.