In vivo, KMF ameliorated IgE-sensitized mouse models of passive cutaneous anaphylaxis (PCA) (82), OVA-induced allergic rhinitis (AR) (reducing IgE, histamine, and MC infiltration) (75), and OVA/IgE-induced paw swelling, hypothermia, and serum levels of histamine, TNF-α, IL-8, and MCP-1 (83). The gene discussed is IGHE; the disease is allergic rhinitis.