Next-generation sequencing of archival tumor tissue identified a TP53 mutation (VAF 4.8%).The sustained remission of both irradiated and non-irradiated lesions, particularly the brain metastases, underscores the potential of this combined approach to achieve durable disease control in advanced NSCLC, even in PD-L1 negative patients. Here, CD274 is linked to non-small cell lung carcinoma.