COPS5 and neoplasm: However, some recent studies suggested the opposite and demonstrated that DAPK1 can act as a tumor suppressor in gastric cancer either via as a downstream target of tumor suppressor Circ1811, instigating IFN-γ induced cell death, or mediating IKKβ/CSN5/PD-L1 axis to enhance natural killer cell killing and inhibiting tumor immune evasion (Figure 5) (33, 82).