In this study, we aim to elucidate the expression levels of CD68 in various DSC types, assess its prognostic value, and explore its correlations with six TIICs (B cells, CD4+ T cells, CD8+ T cells, macrophages, NK cells, and cancer-associated fibroblasts) and four common TICs (PDCD1, CTLA4, IDO1, and CD40). Here, CD40 is linked to cancer.